Although I have not painted a traditional mural (large, even pictorial signs do not really qualify [see Sign Painter]), I did produce a type of mural when I was an Exhibit Designer at the Dawson City Museum.
It was based on a segment of a famous Klondike Gold Rush photograph showing backpacking sourdoughs climbing Chilkoot Pass, silhouetted against the sky. I rendered my mural accordingly in two colors, filling an end wall of the museum's high-ceilinged gold-mining room.
I also helped design a mural painted by Sue Ward for the exterior of Dawson's Good Samaritan Hall. For the background town scenes, I also painted the tiny signs showing in the picture.